ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence.

نویسنده

  • Gerry R Boss
چکیده

Patients: 57 patients (mean age 60 y, 100% men) who presented within 7 days of onset of an acute attack of gout (American College of Rheumatology criteria for acute arthritis of gout), with presence of monosodium urate crystals on arthrocentesis of the primary joint. Exclusion criteria included secondary gout; tophaceous gout; current use of anticoagulants or use of steroids, colchicine, allopurinol, chemotherapy, or immunosuppressive therapy in the past 6 months; recent serum creatinine level > 1.3 mg/dL (114.9 μmol/L); or history of heart failure.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative trial of azapropazone and indomethacin plus allopurinol in acute gout and hyperuricaemia.

This study compared the effects of azapropazone and indomethacin plus allopurinol in the management of acute gout and hyperuricaemia. A group of 93 patients predominantly based in general practice were randomly allocated to the two treatment regimens (azapropazone (days 1-225) or indomethacin (1-28) followed by allopurinol (29-225)) on a double-blind double dummy basis. Azapropazone produced a ...

متن کامل

Gout: an update.

Arthritis caused by gout (i.e., gouty arthritis) accounts for millions of outpatient visits annually, and the prevalence is increasing. Gout is caused by monosodium urate crystal deposition in tissues leading to arthritis, soft tissue masses (i.e., tophi), nephrolithiasis, and urate nephropathy. The biologic precursor to gout is elevated serum uric acid levels (i.e., hyperuricemia). Asymptomati...

متن کامل

Cost-effectiveness analysis of allopurinol versus febuxostat in chronic gout patients: a U.S. payer perspective.

BACKGROUND Gout is a chronic inflammatory condition associated with poor urate metabolism. Xanthine oxidase inhibitors such as allopurinol and febuxostat are recommended to reduce uric acid levels and to prevent gout attacks in adult patients. Under budget-driven constraints, health care payers are faced with the broader challenge of assessing the economic value of these agents for formulary pl...

متن کامل

Febuxostat for prevention of gout attacks.

(1) Febuxostat is a selective inhibitor of xanthine oxidase. Its use in the management of hyperuricemia and gout is being studied. (2) In a 52-week, phase III randomized clinical trial, febuxostat was superior to allopurinol for lowering uric acid levels. Its efficacy in preventing gout attacks was similar to that of allopurinol. Despite a similar rate of adverse effects, individuals on febuxos...

متن کامل

Diagnosis and treatment of gout

To cite: Meltzler M. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014203641 Gout is an ancient disease that has caused pain and suffering over many centuries. The tragedy is that today we have excellent medication for the prevention of chronic gout, yet many people continue to be plagued by gout attacks and develop chronic arthritis. The incidence of gout is i...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Annals of internal medicine

دوره 158 8  شماره 

صفحات  -

تاریخ انتشار 2013